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Drugs and the liver: Metabolism and mechanisms of injury

29 CampisiM.ShinY.OsakiT.HajalC.ChionoV.KammR

Methotrexate Based on 80 publication(s) in Google Scholar Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis

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Cytometry A 58: 167-176

Upon exposure to GSH, redox-driven or binding-induced structural changes modulate their emission, enabling highly sensitive and selective GSH quantification with minimal interference from other thiols such as cysteine and homocysteine [93]