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As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]

Targeting Sleep Physiology to Modulate Glymphatic Brain Clearance Timo van Hattem, Lieuwe Verkaar, Elena Krugliakova, Nico Adelhfer, Marcel Zeising, Wilhelmus H

GLP-1 injections are generally considered safe for weight loss when used under the supervision of a healthcare provider

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Common incretin-related effects discussed in the broader GLP-1 and metabolic drug class may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, constipation, or abdominal discomfort, but trial observations do not establish safe personal use of a research peptide