Like other GLP-1R agonists, when used alone or treated with non-insulin secretagogues, DUL treatment is associated with weight loss or decreased weight gain (107)
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The GLP-1 released from the gut after eating only hangs around for a minute or two [archived link]
Digestive/GI side effects are common: nausea, vomiting, diarrhea, constipation, delayed gastric emptying (gastroparesis) have all been documented
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For those in a maintenance phase after weight loss, microdosing can help preserve metabolic gains without the appetite suppression of higher doses, prioritizing sustainability , tolerability , and resilience important for long-term health optimization