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2** CagriSema resulted in greater weight loss of 22.7% at 68 weeks versus 2.3% in the placebo group when evaluating the treatment effect if all patients stayed on treatment

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To determine whether TBB inhibition preferentially triggers apoptosis of senescent cells, Zmpste24 / MEFs treated with TBB were stained for C 12 FDG to label senescent cells, then stained for Annexin V, an early apoptosis marker, and 7-aminoactinomycin D (7-AAD), a membrane impermeable dye that is generally excluded from viable cells as a later apoptosis marker, and finally analyzed with flow cytometry

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Both RCT and real-world data (RWD) sets comprised unique subgroups, with an overlap observed in only a few clusters