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This study was approved by the Institutional Review Board (IRB) of Severance Hospital, Seoul, Republic of Korea (IRB number 4-2016-0901) and, when required, written informed consent was obtained from patients at the time of blood sampling

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Endothelial 3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation -blocker nebivolol