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If nausea is persistent but not severe, dropping back one titration step for an additional 2 to 4 weeks before attempting the increase again often resolves the issue

Finally, the MK-801-induced increase in the number of pyknotic nuclei was attenuated by caspase-3 inhibitor, Ac-DEVD-CHO (data not shown) pointing to apoptosis as a main executor of MK-801-mediated neuronal cell damage

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Palmu E, Hedlund K

It may deplete glutathione, the methyl group required to lower homocysteine, thus only making things worse