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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

The preclinical data is generally consistent and encouraging

Improper storage, and especially exposure to heat, can reduce potency or even cause the vitamin to break down over time, rendering it less useful in addressing deficiencies and supporting overall health

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For instance, a family history of cardiovascular disease can clinically help identify individuals at high risk of non-stroke cardiovascular events, irrespective of ethnicity, and those at increased risk of stroke among African Surinamese [44]