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15 The study concluded that both LSG and LRYGB groups demonstrated statistically equal efficacy in reducing excessive body mass index and improving quality of life up to 3 years after surgery

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Alters SE, McLaughlin B, Spink B, Lachinyan T, Wang CW, Podust V, Schellenberger V, Stemmer WPC (2012) GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohns disease model

Weeks 24: What Most People Notice Progressively reduced appetite Reduced cravings for trigger foods Eating smaller meals without effort Increased awareness of hungerless emotional or habitual eating Calorie intake drops naturally because of appetite control Early Results Some patients begin seeing measurable weight loss by weeks 34, though results vary based on: Starting weight Calorie intake Activity level Metabolism Dosage A large clinical study published in the New England Journal of Medicine found that patients lost an average of ~6% of body weight by week 12 and ~15% by week 68 when combined with lifestyle changes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Wilding J.P.H., Batterham R.L., Davies M., Van Gaal L.F., Kandler K., Konakli K., Lingvay I., McGowan B.M., Oral T.K., Rosenstock J., et al