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Semaglutide may worsen diabetic retinopathy in some patients with pre-existing disease, particularly during rapid improvement in glucose control

This contraindication reflects the theoretical concern that GLP-1 receptor stimulation could promote recurrence or progression of residual C-cell disease, even though human C-cells express minimal GLP-1 receptors

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Figueiredo, L., Santos, R

If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs