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Canada GLP-1 Agonists Weight Loss Drugs Market Estimates and Forecasts, 2018-2030 (USD Million) 7.2.4

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Data demonstrates that as many as 74% of people experience side effects on standard GLP-1 dose schedules, typically gastrointestinal side effects

Some patients report that leg cramps worsen after dose increases, suggesting a dose-dependent relationship, though this remains an individual variation rather than a universal effect

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5.3 Overcoming the bloodbrain barrier (BBB): nanocarrier-based drug delivery The BBB severely restricts CNS penetration of most therapeutic agents