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In an inflammatory setting induced by IL-1, increased levels of hypoxia-inducible factor-2 (HIF-2) coupled with diminished GPX4 expression in chondrocytes increase their susceptibility to ferroptosis ( Figure 4 ) (161)

In the cream formula, Dihexa is dispersed in an appropriate matrix for easy application and absorption

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Keller J, Binnewies U, Rsch M, Juul Holst J, Beglinger C, Andresen V, Layer P (2015) Gastric emptying and disease activity in inflammatory bowel disease

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