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When you consider skin is the largest organ of the body and that under a microscope pores look like little holes, then you can create a visual that whatever you put on your skin drops in through the pores into the bloodstream

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Consider switching to a non-oral contraceptive method (such as an IUD, patch, or implant), or use an additional barrier method (such as condoms) for at least 4 weeks after starting semaglutide and for at least 4 weeks after each dose increase

Published 2019 Aug 9

Peri-lesional injection requires precise anatomical knowledge and a higher technical skill level, and the marginal benefit over subcutaneous delivery is not clearly established

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