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Ou, M.-L

FGF21 is produced primarily in the liver in response to metabolic stress and acts as a systemic regulator of energy balance stimulating fatty acid oxidation, promoting adiponectin secretion, and supporting healthy mitochondrial function in brown adipose tissue.* FGF21 levels are closely correlated with metabolic flexibility the ability of cells to switch efficiently between fuel sources

European Journal of Nutrition

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Receptor Structure and Activation ERRs share the typical nuclear receptor domain structure, with an N-terminal activation domain, a central DNA-binding domain, and a C-terminal ligand-binding domain (LBD)

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