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"Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial." NEJM, 2023;389:514526

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Alongside its use for overweight and obesity, studies of the drug focused on treating non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH), a condition where fat builds up in the liver

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Hence, the increased incidence of hypoglycemia caused by the combination of GLP-1 receptor agonists and sulphonylureas may be linked to the uncoupling of GLP-1 from its glucose dependence

The individual variation suggests that personal genetics, hydration habits, and baseline salivary function play significant roles beyond the medication itself