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It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]

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Thereby, As shown in Figure 1B, NAC also exert pro-osteogenic effect through the antioxidative activity in pre-osteoblastic cells under stress conditions induced by H 2 O 2 (Lee et al., 2015), high glucose (Liu and Yang, 2016), lipopolysaccharides (LPS) (Li et al., 2023), 7-ketocholesterol (7KC) (Ouyang et al., 2022), dibutyl phthalate (DBP) (Zhang et al., 2017), dexamethasone (Li S

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