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The study found that tissue glycine levels in many individuals fall below the Michaelis constant for the enzyme glutathione synthase, meaning the enzyme cannot operate at full capacity

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Trends in Endocrinology & Metabolism, 31 (6), 410-421

Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years

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[12] The most noteworthy effect of GLP-1 is its ability to promote insulin secretion in a glucose-dependent manner