The possible explanations for the higher insulin sensitivity in PWS could be the relatively lower visceral adipose tissue (VAT) and higher subcutaneous adipose tissue (SAT) than BMI-matched controls, as well as the predominant accumulation of subcutaneous fat in the trunk and proximal limbs, with a lower ratio of trunk-to-appendicular fat (167, 185, 186)
This structural difference explains why tirzepatide users report nausea in roughly 2533% of clinical cases during dose increases, compared to 2026% for semaglutide at comparable timepoints
Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock
Multiple presentation of mitochondrial disorders
Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which are generally mild to moderate and tend to diminish with continued use
Thome AD, Harms AS, Volpicelli-Daley LA et al (2016) microRNA-155 regulates alpha-synuclein-induced inflammatory responses in models of Parkinson disease
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