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In hepatic stellate cells, curcumin activated PTEN by downregulating DNMT3b and through miR-29b-mediated demethylation (Zheng et al., 2014)

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PDE5i reduced the M1/M2 ratio of gWAT macrophages of obese mice

Lets take a closer look at how these two interventions can work synergistically

Its combined appetite-suppressant and energy-expenditure effects make it more effective than traditional GLP-1 monotherapies, offering a potential breakthrough in obesity treatment