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The absence of pain, bleeding, itching, or visible lumps during bowel movements indicates normal anal health, while any combination of these symptoms suggests hemorrhoids requiring evaluation

Wegovy is contraindicated in patients with a family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Since improved mortality has not been demonstrated for any of these treatment-induced histological changes, further long-term follow-up studies are needed to demonstrate that halting disease progression and/or reduction of steatosis, resolution of steatohepatitis or regression of fibrosis translate into a reduced risk of clinical outcomes ( LoE 3, strong consensus )