This complex interaction affects essential metabolic pathways (Herbert et al., 2023), like the saccharopine pathway, involved in lysine degradation and potentially contributing to metabolic adaptations required for oxidative phosphorylation in co-infected individuals
However, in the context of elevated vitamin C uptake, high vitamin C can act as a pro-oxidant by reducing iron and promoting lipid peroxidation, GPX4 inactivation, and ferroptotic cell death 125
Individual experiences differ based on personal factors, program participation, and lifestyle choices
For many dogs, antioxidant supplements are tolerated, but "safe" depends on the dog's condition, the product's quality, and what medications are on board
Lipid homeostasis and regulated cell death
M.HumbertM.SouzaR.IdreesM.KawutS