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Migraine sufferers frequently describe the pain as being limited to one side of the head (Digre 2011a)

This is particularly relevant for critical-dose drugs such as anticoagulants, antiepileptics, and immunosuppressants

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The combined aqueous solutions were extracted with THF/ethyl acetate (0.5 : 0.5 L), and the combined organic layers were evaporated to dryness