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These different complementary interventions were reported to be successful, with the dysmetabolic impairment found to be significantly reduced (6, 7, 9, 10, 19, 27)

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Noticeably, synaptamide, a DHA metabolite analog of the endocannabinoid anandamide, ameliorates cAMP signaling and boosts the NSC differentiation impaired by ethanol (46) (Figure 2)