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Its binding to VMAT2 is very strong, making it's effect appear irreversible, with trace amounts of the drug remaining bound to vesicular membranes for many days, and its clinical effects lasting many days to weeks, and may persist until new transporter proteins are synthesized (German et al, 2015

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In a survey from Business Group on Health, a nonprofit that works with companies and policymakers to reduce employee healthcare costs, nearly 80% of employers said GLP-1 drugs are a primary factor driving up premiums for employer-sponsored health benefits

Attractive targets include members of the LOX family, namely LOX and LOX-like 2 (LOXL2), which mediate collagen and/or elastin crosslinking [97, 98], thereby contributing to ECM remodeling in the tumor microenvironment

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doi: 10.1021/bc060173z