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At a median of 75-month follow-up, patients demonstrated markedly improved Knee Society pain and function scores and decreased pain compared with preoperative scores

7 In the phase 2 monotherapy trial these events were generally mild to moderate, most frequent during dose escalation, and tended to diminish with continued treatment

And researchers studying KPV point to the need for human research

Slight sting for a second or two

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Even in this more challenging population, the combination produced 13.7% weight reduction versus 3.4% for placebo, along with dramatic improvements in glycemic control