Studies show that sublingual (under the tongue) and nasal forms of B12 supplements offer a similar absorption rate as injections (Temova Rakua et al., 2022)
It's a game-changer in a research context
The compound has been studied for its interaction with nicotinamide N-methyltransferase (NNMT) , an enzyme that catalyzes the methylation of nicotinamide
These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]
If not, consult a professional to receive B12 through pill forms or shots.
[DOI] [PubMed] [Google Scholar] Higgins 2002 Higgins JP, Thompson SG