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FIGURE 4 Novel drug modalities for NRF2 activation Up to date, the only NRF2 activators in clinical use are DMF for MS (Rosito et al., 2020), and more recently Omaveloxolone, a semisynthetic terpenoid with potent NRF2-activating effects gained FDA approval in Februrary 2023 for the treatment of Friederichs ataxia ( However, most NRF2 activators are of electrophilic nature and exhibit unpredictable poly-pharmacology
DIM, indole-3-carbonol, and sulforaphane are examples of compounds derived from glucosinolates found in cruciferous vegetables, and they help to modulate detoxification in the body
Often referred to as the bodys master antioxidant, glutathione is naturally produced within our cells and plays an important role in maintaining everyday wellness
B.DiamantM.FerranniniE.NauckM.et al (2015)
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Oxidation of biological systems: Oxidative stres phenomena, antioxidants, redox reactions, and methods for their quantification
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