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doi:10.1016/j.febslet.2014.07.005 156

Considering the overlap of natural ligands of GPR40 and GPR120, it has been difficult to study them individually and understand their individual physiology, while recent data indicate that indeed these two receptors work synergistically, to exert anti-diabetic activity in vivo from the gut (289), and the brain (253)

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Furthermore, it is hypothesised that incretins are having an effect in the brain via palatability and reward pathways (e.g

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