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This specific ICV dose was empirically derived from a systemic equivalent of 10 mg/kg, adjusted based on the approximate brain-to-body weight ratio of a mouse, approximately 1:100

It showed modest results and later studies did not support a strong enough obesity-drug profile for commercial viability

Preclinical and clinical evidence supporting melatonin use in PCOS is summarized in Table 3

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This direct action allows for more specific study of IGF-1 receptor-mediated effects independent of the complex control mechanisms involved in growth hormone signaling