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When pain is detected, serotonergic neurons in the brainstem (in a region called the rostral ventromedial medulla) are activated and release serotonin

Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death

Ashiq Mohamed Consultant Dermatologist Kauvery Hospital, Chennai

Translation: Researchers will continue to pursue it, but its not ready for primetime

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PHARMACOLOGY AND MECHANISM OF ACTION Alpha-lipoic acid and its reduced form, dihydrolipoic acid, are described in scientific literature as participating in cellular redox cycling