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In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]

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However, gastrointestinal side effects, including diarrhea, constipation, and abdominal discomfort, have been reported in approximately 35% of patients, especially during initial usage

Alcohol Considerations Alcohol tolerance often decreases significantly on Retatrutide