Over 99% of investigational drugs, participating in over 200 clinical trials, failed to receive approval for the treatment of Alzheimers disease [1]
Una finestra d'azione stretta rende difficile trasferire i risultati dei modelli a sistemi piu complessi
Since the importance of oxidative stress in the development of age-related neurodegeneration is well established, a number of antioxidant compounds are considered promising in prevention of neurodegenerative disorders, including vitamin E, melatonin, green tea polyphenols, resveratrol, and others [4]
These genetic variations disrupt normal functions that occur in cells, ultimately leading to neurodegeneration (Kovacs, 2016)
At basal or moderate levels these species have various physiological functions
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