Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone
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Across this body of research, no significant toxicity has been reported at doses ranging from 1 g/kg to 10 mg/kg in rodent models
However, when paired with potent GLP-1 and GIP agonism, the glucose-raising effect of glucagon is overridden by the insulinotropic effects of the other two pathways
Absence of expected improvement by mid-protocol (4-6 weeks) warrants reassessment
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