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(480) reported that an increase in opportunistic pathogens, including Actinomyces , Erysipelaclostridium , Streptococcus , Veillonella , Rothia , and Enterobacter , was positively correlated with both the initial diagnosis and the severity of the illness

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Additionally, increased intestinal permeability, called leaky gut, allows gut-derived pro-inflammatory molecules and microbial metabolites to enter systemic circulation, enhancing systemic inflammation and influencing central neuroinflammatory processes (Fig