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Response: We thank the commenters for their interest in the measure

PMC+1 However, a 2025 systematic review in HSS Journal found 35 preclinical studies but only a single small retrospective human series (12 patients)

Although treatments are available for some neurodegenerative diseases, there are currently no cures

PC-SOD (recombinant human SOD1 covalently coupled to four molecules of lecithin) is a potent superoxide-radical scavenger with a 100-fold increase in protective effects against endothelial cell injuries, compared to unmodified SOD 567,568

Cyanocobalamin contains a small amount of cyanide, but it is not considered to be harmful

100 g wet weight of cells were harvested by centrifugation (10 min at 1000 g ), washed twice in Tris-HCl buffer (10 mM Tris-HCl, pH 7.5), and chilled on ice