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This inhibitory action was attributed to Norleual-AngIVs capacity to prevent HGF dimerization, a crucial step for c-Met activation, while Dihexa was subsequently confirmed to act as an agonist within this system

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These profound effects on brain structure and function position Dihexa as a promising candidate for cognitive enhancement and the regeneration of neural networks compromised by injury or disease

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The investigation into the AT4/HGF/c-Met system link revealed distinct roles for different compounds