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Through a process catalyzed by the enzyme Glutathione S-Transferase (GST) , glutathione physically attaches (conjugates) itself to these dangerous electrophilic xenobiotics and intermediate metabolites

Cysteine is released from extracellular glutathione by -glutamyl-transferase (GGT) located on the apical surface of the kidney, intestine and the epithelia of most transporting ducts, including the liver and bile ducts [37]