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There are three classical signal transduction pathways involved in the development of endoplasmic reticulum stress: IRE1, PERK, and ATF6

The relationship between SIRT1 and NAMPT has been well established

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Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y

An inducible Clec7a-CreERT2 mouse line enables selective genetic tracing of proliferative-region-associated microglia (PAM) and DAM in the CNS ( in vivo tracing demonstrated state transitions, exhibiting reversible microglial plasticity