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Activation of I 1 receptors in these regions facilitates endogenous sympatholytic signaling, synergizing with the central 2 pathway to reduce blood pressure and peripheral resistance (Szabo, 2022)

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Methods Mice Wild-type C57BL/6J (B6) were purchased from Charles River (stock number JAX 000664)

Research without UV co-exposure shows minimal visible pigmentation despite confirmed MC1R activation

One-way ANOVA comparison between MIA mice treated by vehicle versus MT-II showed a significant treatment interaction between groups: F( 3,30 ) = 19.33

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