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[3] These include poor growth, apathy, having no desire for food, and developmental regression

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The mechanism of this is unknown but poor penetration of peripheral leptin to hypothalamic regions due to reduced capillary transport system in hypothalamic microcirculation could be responsible for its limited efficacy as an anti-obesity drug (47)

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Therefore, we developed novel dual-GLP-1/GIP receptor agonists that contain cell-penetrating motifs in their amino acid sequences that can enhance BBB penetration

Some of the potential benefits of B12 injections include: 1