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Despite the intestinal barrier being designed to limit the translocation of luminal components, certain factors disrupt its integrity including genetic predisposition, gut microbiota dysbiosis and environmental factors such as those present in food and oral therapeutics (Fig

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These compounds address different physiological goals and carry very different evidence profiles

But beyond weight loss, AOD 9604 offers other benefits, including: AOD 9604 was originally developed to treat obesity, but today, many people use it as a weight-loss treatment

In preclinical studies this reduced fat-cell size without changes to diet