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The combination group showed larger changes in body weight and whole-body adiposity than the diet-change-only group during the experimental period

Study participants receiving active treatment saw three times the weight loss experienced by those in the placebo group

Use of certain medications that may interact with B12 or choline metabolism (e.g., metformin, proton pump inhibitors, or anticholinergic drugs)

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Avoid evening administration, as the increased energy levels may interfere with sleep in sensitive individuals