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Reduced saliva flow (known as hyposalivation) significantly increases the risk of dysbiosis and is associated with higher rates of caries, periodontal disease, and oral infection

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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms

However, under the hypoxic conditions of tumor cells, the azo bonds in the COF structure are activated, triggering degradation and drug release

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