With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
All linked inline where referenced
Those questions are structural: Does the weight loss continue, plateau, or rebound past 24 weeks
Each delivery method involves trade-offs between convenience, bioavailability, cost, and personal preference
Experts say that metformin can lead to modest weight loss through many pathways, but these findings primarily emphasize the value of exercise
In animal research, giving Akkermansia to mice improved features of diet-induced metabolic problems (Everard et al., 2013), and a small human trial found that pasteurized Akkermansia was safe, well tolerated, and linked to some improved metabolic markers in adults with overweight or obesity (Depommier et al., 2019)