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A schematic picture illustrating possible links between p53 and IGF-1R is presented in Figure 1

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In this article, we have presented a conceptualization of neurodegenerative disorders as metabolic icebergs, which conveys the hallmark clinical, anatomical, and pathological features (tip) as late-stage effects of impaired mitochondrial biology (bulk), which in turn is induced by a suite of environmental and genetic factors (base)