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In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

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Clinical studies show afamelanotide significantly increases sunlight tolerance, reduces pain from light exposure, and improves quality of life for EPP patients