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5 Challenges and future directions in microbiota-based interventions for hypothyroidism Although microbiota-targeted strategies present a promising adjunct in the management of hypothyroidism, several critical challenges must be addressed to fully realize their therapeutic potential (Figure 5)

Abbreviations Cu: Copper IUD: Intrauterine contraceptive devices IV: Intravenous CPK: Creatine phosphokinase ALT: Alanine transaminase AST: Aspartate aminotransferase Hb: Hemoglobin G6PD: Glucose 6-phosphate dehydrogenase GI: Gastrointestinal EDTA: Edentate calcium diphosphate DMPS: Dimercaptopropane sulfonate-l-sulphonate ECMO: Extracorporeal membrane oxygenation References Tapiero H, Townsend DM, Tew KD (2003) Trace elements in human physiology and pathology Copper

doi: 10.1016/S1522-1865(02)00159-2 46 MedinaRJONeillCLODohertyTMKnottHGuduric-FuchsJGardinerTAet al

Jun 2017;21(2 Suppl):66-72

The efficiency of RCM is highly influenced by the ring size of the macrocyclic cross-linking