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Occasional timing shifts (within 24-48 hours of usual injection day) rarely cause problems due to the 7-day half-life's built-in buffering

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These technicalities matter because they open avenues for off-brand drugs to proliferate

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Eligibility criteria Studies were included if they met the following criteria, according to the PICOS framework: Population Adults ( 18 years) only at high risk for cardiovascular disease (CVD) or with established CVD (coronary artery disease, heart failure, prior myocardial infarction, stroke)