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An ideal PD model would exhibit a high level of construct validity, indicating a similar disease pathogenesis (e.g., involving oxidative stress, inflammation, complex I inhibition, or proteasome inhibition), face validity, reflecting comparable symptoms (e.g., dyskinesia, rigidity), biochemistry (e.g., decreased striatal DA and altered downstream neurochemistry), and pathology (nigrostriatal tract degeneration and Lewy body formation) to the human condition, as well as predictive validity, signifying the capacity to accurately identify clinically effective treatments (Betarbet et al
The number of episodes has dramatically decreased and when they do occur, they are less severe
6.74 cm), produced roots that were 2.5 times longer (28.56 cm vs
Next, microarray analysis was performed using samples in which the opacity was reduced by glutamate, and genes whose expression increased with galactose culture and decreased with the addition of glutamate were extracted
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