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In conclusion, the decision to explore glutathione for skin lightening should be carefully considered under a qualified dermatologists guidance

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Institute of Physics Publishing Sun X, Berger RS, Heinrich P, Marchiq I, Pouyssegur J, Renner K, Oefner PJ, Dettmer K (2020) Optimized protocol for the in situ derivatization of glutathione with n-ethylmaleimide in cultured cells and the simultaneous determination of glutathione/glutathione disulfide ratio by HPLC-UV-QTOF-MS

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The study protocol was approved by the ethics committee of Louisiana State Health Sciences Center-Animal Care Committee (Animal Care protocol number P-15-006), and all the methods were carried out following the approved guidelines