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Cannabinoid receptor 2 is necessary to induce toll-like receptor-mediated microglial activation

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This also suggests that future clinical trials using SAM to treat depression may need to consider chronotypes as a confounder that may have been the origin of failed clinical trials

28 Wnt signaling was associated with carriage of the A allele of the rs2069502 CDK4 SNP (including a 1.5-fold change in expression of -catenin, a primary modulator of WNT signaling and a concomitant 1.4-fold change in expression of TCF4 , a developmental transcription factor that is a downstream target of WNT (Table 4, Supplementary Figure S4)

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